Active Ingredients

Ingredients Specifically Formulated For Opiate Withdrawal and Detox

The active ingredients in both Withdrawal Ease product formulations are specifically chosen for their high bio-availability and purity.  High quality ingredients delivered at the effective dose is critical for reducing the severity of common opiate withdrawal symptoms. We have recently improved both formulations after analyzing the results from over 80,000 products sold. We use only the highest quality ingredients manufactured and processed under GMP (Good Manufacturing Processes) and FDA certified guidelines. The product also includes 14 additional amino acids, vitamins and minerals that provide you with a fully comprehensive nutritional supplement that is specifically formulated for opiate withdrawal and detox. All of these ingredients — some of which are very difficult to find — bought separately at a nutritional supplement store would cost up to $300. The Withdrawal Ease System is the only withdrawal treatment that combines all of these ingredients into two convenient formulations for both daytime and nighttime symptoms. It’s simple, safe and effective when taken as directed and while following our instructions in The Opiate Withdrawal Survival Guide.

We chose to list the details of some particular ingredients due to their history and in order to give you some more detailed background on the active properties of the product. We also hope that you find some of the background information interesting and educational. You can find a full list of product ingredients at the bottom (scroll alllll the waaay down!) of this page and of course on the bottle labels themselves. I have referenced some abstracts and clinical trials in the content below: some of these studies can be found on our page called “How It Works.” Abstract data and citations are also available upon request.


A Closer Look at Some of Withdrawal Ease’s Active Natural Ingredients


Withdrawal Ease Ingredient - Passion Flower


Passion Flower

Doctors of Naturopathic Medicine use it for: Anxiety, stress, tension, insomnia, digestive problems and menstrual cramps.

Pharmacology: Passion Flower contains alkaloids, flavonoids and passiflorine which have a chemical make-up similar to morphine and other opiates. As a result, it is believed that these compounds react with the Central Nervous System to help relieve anxiety, however there are also believed to be energy inducing qualities in this reaction as well.

Efficacy: There have been many randomized clinical trials using passion flower and placebos which have reported compelling results for the use of passion flower in patients with anxiety and insomnia. Commission E. ( The FDA’s Counterpart in Europe) has approved the use of passion flower for anxiety, restlessness and insomnia.

Interesting Tidbits: The Incas used to brew passionflower tea for its calming effects. And some Christians believed that the flower contains divine properties due to its resemblance to a crucifix. I myself have not been able to see the connection but maybe you can!


Withdrawal Ease Ingredient, Lemon Balm


Lemon Balm

Doctors of Naturopathic Medicine use it for: Immune-booster, insomnia, viral infections, digestive problems and wound healing.

Pharmacology: The active ingredients include polyphenols and eugenol. The polyphenols are claimed to be anti-infective/anti-microbial agents. The eugenol is said to have anesthetic properties. The essential oils of the herb are purported to have soothing and calming effects.

Efficacy: In Germany, randomized controlled trials were conducted comparing lemon balm to Halcion (a prescription sleep-aid) and was proven to be as effective in combating insomnia. Commission E. in Europe has approved it for use as a sedative.

Interesting Tidbits: Lemon balm was widely used by Arabs in the 10th Century as an anti-anxiety remedy. In Medieval Europe, the Emperor Charlemagne was said to be a huge fan of lemon balm and ordered it grown in every one of his gardens.


Withdrawal Ease Ingredient - Pomegranate



Doctors of Naturopathic Medicine use it for: Arterial health, common colds and rhinovirus infection.

Pharmacology: Pomegranate contains a heavy dose of antioxidants called polyphenols which are said to help break down plaque in the arteries and promote vascular health.

Efficacy: Israeli studies have demonstrated promising cardiovascular health benefits from pomegranate. The fruit is also the subject of many clinical trials for its potential anti-carcinogen effects with prostate and breast cancer.

Interesting Tidbit: The Greek Goddess Persephone, Daughter of Demeter, was tricked by Hades into eating Pomegranates and thus was condemned to live in the underworld for four months out of every year. Demeter (aka The Goddess of the Harvest) protested of her daughter’s imprisonment by prohibiting any fertility on Earth during those four months. This prohibition became the Greek explanation for the seasons.


Withdrawal Ease Ingredient - Slippery Elm Bark


Slippery Elm Bark

Pharmacology: Slippery Elm provides Mucilage which is a type of complex sugar called a polysaccharide. When elm bark is moistened, it is believed to help soothe the smooth muscles of the GI tract and provide easier digestion.

Efficacy: The FDA calls slippery elm “an excellent demulcent”. That’s a fancy, clinical term for an agent that helps lubricate or smooth the GI tract.

Interesting Tidbit: There used to be a law called the “slippery elm bark law” that only allowed the elm to be used for certain purposes and even required that it be cut to certain lengths. In the 1800’s, Slippery Elm was also used as a digestive aid, as well as a simple treatment for indigestion.


Withdrawal Ease Ingredients - Anise



Doctors of Naturopathic Medicine use it for: Upset stomach and congestion

Pharmacology: Anise contains anethole (a phytoestrogen) which is believed to help treat indigestion, insomnia and coughs.

Interesting Tidbit: Anise is typically used in “black licorice” instead of real licorice since the “real” thing can sometime produce hypertension and anxiety.


Withdrawal Ease Ingredients - Horseradish



Doctors of Naturopathic Medicine use it for: Digestion, expectorant and circulatory stimulant.

Pharmacology: Horseradish contains enzymes, glycosides, resin and vitamin C which are said to help indigestion and help the liver break down fatty acids.

Efficacy: Horseradish is known to have diuretic properties and has been used to treat coughs, colds and even urinary tract infections.

Interesting Tidbit: Horseradish doesn’t have a colorful past like some of our other ingredients here. However, that doesn’t mean that it hasn’t had any historical impact. For centuries horseradish has been used as a substitute or alternative to mustard, and also is the chief ingredient in Arby’s “Horsey Sauce”. It has also been used widely to mask the taste of poorly prepared prime rib (which happens with alarming frequency unfortunately).


Withdrawal Ease Ingredients - Echinacea



Doctors of Naturopathic Medicine use it for: Immunity boost, fighting colds and viral infections, healing wounds.

Pharmacology: Echinacea contains fatty acids, insulin, plant sterols and polysaccharides which can help boost the immune system by helping macrophages in the bloodstream seek and destroy viral invaders. Echinacea also purportedly energizes other essential white blood cells such as T lymphocytes which are natural viral “killer-cells” to help fight infectious agents. Echinacea is also considered a potent treatment for reducing the severity and duration of colds and flu.

Efficacy: The Journal of Family Practice Medicine published results from several double-blind studies with over 1,000 participants — half of whom took echinacea at the onset of cold symptoms, and half of whom took a placebo at the onset of cold symptoms. Of the population that took Echinacea, the duration of their colds averaged 4 days while those on a placebo experienced colds that lasted 8 days. Commission E in Europe endorses the use of Echinacea to treat colds and the flu.

Interesting Tidbit: Echinacea gained popularity in the late 1800’s as a cure for insect and snake bites, and a blood purifier. It was the main ingredient in Dr. Meyers Blood Purifier which falsely claimed to cure rattlesnake bites. This became the origin of the term “Snake Oil Salesman”.

Echinacea is also the main, active ingredient in the popular over-the-counter remedy “Cold-Eze” which I personally swear by.


Withdrawal Ease Ingredients - Peppermint



Doctors of Naturopathic Medicine use it for: Muscle pain, insomnia, stomach pain, IBD (Inflammatory Bowel Syndrome), coughs and headaches.

Pharmacology: Peppermint gets its power from Menthol. Menthol can be used topically and internally as an anesthetic to help numb pain and relax smooth muscles. Smooth muscle relaxation has been said to relieve tension headaches caused by muscle spasms in the neck and jaw.

Efficacy: Peppermint is been indicated for being useful in the treating colds by the FDA and also is widely used in Europe as an active ingredient in popular analgesics and cold remedies. Peppermint has also been approved for the above uses by Commission E.

Interesting Tidbit: Native Americans used Peppermint to treat coughs and colds.


Withdrawal Ease Ingredients - Green Tea


Green Tea

Doctors of Naturopathic Medicine use it for: Headaches, energy, cardiovascular health and diarrhea.

Pharmacology: Green Tea has a rich supply of anti-oxidants called polyphenols. Antioxidants have cell and tissue healing properties that can help repair damaged tissue and organs. Polyphenols in particular have been purported to prevent many types of cancer and prevent certain types of heart disease. The caffeine in the tea is a natural stimulant and helps provide energy and alertness.

Efficacy: Antioxidants have been the subject of numerous clinical trials mostly around the prevention of cancer and cardiovascular disease. Japanese controlled trials produced compelling evidence that those people who drank green tea regularly are less prone to certain cancers such as stomach, lung and breast cancers.

Interesting Tidbit: Tea is the only plant I know of that has caused a war (the “War on Drugs” notwithstanding). The Boston Tea Party (when British shipments of tea were poured into the Boston harbor in protest of British tariffs) was considered the beginning of the Revolutionary War.


Withdrawal Ease Ingredients - Panax Ginseng


Panax Ginseng

Doctors of Naturopathic Medicine use it for: Rebuilding strength and vitality, energy, alertness, mental acuity and helping to relieve
stress and low libido.

Pharmacology: Ginseng contains hormone-like saponins and ginsenosides that work on the central nervous system to help counteract damage caused by physical and emotional stress and fatigue. The hormone-like compounds also help to act as a non-caffeine stimulant.

Efficacy: In a European study comprised of roughly 250 participants who complained of persistent general fatigue, half of the participants were given ginseng and half were given a placebo. The group that received ginseng demonstrated significantly less lethargy and it was concluded that ginseng helps fight fatigue by stimulating the adrenal glands.

Interesting Tidbit: In the early 1700’s, Ginseng was so highly prized in China that many Americans exported American-grown Ginseng which could fetch almost $1 per pound on the Chinese market. That was a lot of money back then.


Withdrawal Ease Ingredients - Mucuna Prureins


Mucuna Prureins

Doctors of Naturopathic Medicine use it for: Restless Leg Syndrome (RLS), depression, energy/drive.

Pharmacology: Mucuna Prureins contains high concentrations of levadopa which is a precurser to dopamine — a neurotransmitter that is located in the “pleasure centers” of our brains. People who are depressed or who have low energy usually have decreased dopamine levels. Levadopa has been said to help increase a person’s energy levels and also help relieve depression.

Efficacy: Most studies and literature reviews of Mucuna Prureins pertain directly to its potential treatment of Parkinsons. There are several abstracts that cite the tertiary benefits of the plant for depression, sex drive and the relief from RLS.

Interesting Tidbits: The plant itself looks like a large furry caterpillar and is called the “itch bean” by some because of its extremely itchy fur. Its hairs are sometimes the main ingredient in “itching powder”.


 Withdrawal Ease Ingredients - Cayenne


Cayenne (Red Pepper)

Doctors of Naturopathic Medicine use it for: Diarrhea, chronic pain/nerve pain, muscular aches and pains, influenza, headaches and the “chills”.

Pharmacology: Cayenne contains capsaicin and vitamins. The capsaicin has been purported to interfere with Substance P. which is a chemical that sends pain signals from the nerves to the brain. The method of action is commonly referred to as “counter-irritation”, which in plain terms confuses the central nervous systems’ ability to report pain back to the brain.

Efficacy: Capsaicin has been approved by the FDA as a topical agent to help relieve sore and pulled muscles, and is used in many over-the-counter joint and muscle pain relievers. A VA hospital in the US conducted a trial among roughly 150 patients suffering from osteoarthritis, a condition that causes severe joint pain. Half of the group received a capsaicin cream rubbed onto their joints and the other half received a placebo. The participants receiving the capsaicin cream reported significantly more pain relief that the control (placebo) group.

Interesting Tidbits: Colonial Americans dusted cayenne pepper on their children’s thumbs to prevent thumb sucking. Yowch!


Withdrawal Ease Ingredients - Ginger



Doctors of Naturopathic Medicine use it for: Nausea, morning sickness, arthritis and digestion.

Pharmacology: Ginger contains a blend of amino acids, resin, starch and vitamins which are primarily said to serve as a gastrointestinal anti-spasmodic.

Efficacy: Ginger’s efficacy for use as a gastro-intestinal anti-spasmodic (i.e. it calms your belly) has been exhaustively studied by some of the most prestigious clinical boards and associations in the world, including the American Medical Association and the British Journal The Lancet. Most clinical trials have been dedicated to ginger’s anti-nausea indications. Additionally, trials have reported superior outcomes when it comes to fighting nausea compared to placebos and even popular over-the-counter anti-nausea medications such as Dramamine.

Interesting Tidbits: Chinese sailors often combat seasickness by chewing on a piece of ginger root.


Withdrawal Ease Ingredients - Tumeric



Doctors of Naturopathic Medicine use it for: Immunity booster, digestive problems, diarrhea and arthritis.

Pharmacology: Tumeric contains Curcumin which acts as an immune stimulant, an anti-inflammatory, antioxidant and helps liver function. One of Curcumin’s many functions is that it stimulates the production of bile which helps break down fats and helps kill certain pathogens in the digestive tract. Curcumin also acts as a pseudo-COX-2 Inhibitor which is the active ingredient in many anti-inflammatory drugs that treat osteoarthritis.

Efficacy: In India (where Tumeric is widely used in curries and other traditional Indian foods), Tumeric has been found to be effective in the treatment of arthritis pain, without the gastrointestinal side effects of NSAIDs.

Interesting Tidbit: Ancient Chinese and Greeks used Tumeric’s striking yellowish color to make fabric dyes.


Withdrawal Ease Ingredients - Milk Thistle Extract


Milk Thistle Extract

Doctors of Naturopathic Medicine use it for: Cirrhosis, Drug-induced liver damage and toxin-induced liver damage.

Pharmacology: Milk Thistle contains a blend of compounds called silymarin which is said to be a powerful liver protectant. It is thought to help repair damaged liver cells and also helps blocks certain toxins from entering the liver.

Efficacy: Silymarin is sometimes considered the most effective treatment for poisoning from certain mushrooms. Several studies have also evaluated milk thistle extract for its healing properties in damaged liver cells due to cirrhosis and drug-induced liver damage. Those that took milk thistle extract in several of these controlled trials had significantly less elevated liver enzymes (which is an indication of reduced liver function) than the control group.

Interesting Tidbit: Milk Thistle extract has been used to treat liver damage for more than 2,000 years!


Withdrawal Ease - Valerian Root Extract


Valerian Root Extract

Doctors of Naturopathic Medicine use it for: Insomnia, anxiety, headaches and muscle spasms.

Pharmacology: Valerian contains valepotriates which have a sedative effect and are said to produce sleep as quickly as some benzodiazapines (Xanax and Klonopin). With Valerian, not only is the onset of sleep hastened but also the quality of sleep is improved. In a German study with over 70 chronic insomniacs, with half of the participants taking Valerian and half taking a placebo, the Valerian group achieved significantly faster sleep and awoke more well rested than the placebo group.

Interesting Tidbit: Valerian tea was a popular drink for the British in World War 1 in order to calm nerves due to incessant bombing and artillery fire.


Opiate Withdrawal Natural Supplement System Product Ingredients

Full ingredient list: Withdrawal Ease Daytime Formulation:

  • Passion Flower
  • Lemon Balm
  • Guar Gum
  • Pomegranate
  • Arabic Gum
  • Elm Bark
  • Horse Radish Ext. 4:1
  • Mucuna Prureins Ext. 20%
  • Echinacea Angustifolia Ext. 4%
  • Peppermint Leaves
  • Green Tea Ext. 50%
  • Panax Ginseng Ext 4%
  • Anise Seed Powder
  • Cayenne Pepper
  • Ginger Ext. 4:1
  • Tumeric Ext 95%
  • Vitamin B1 – Thiamine
  • Vitamin B6 – Pyridoxine HCL
  • Folate – Folic Acid
  • Vitamin B12 – Cyanocobalamine
  • L-Tyrosine
  • Zinc
  • Copper
  • Magnesium (Oxide)
  • Magnesium (Stearate)

Full ingredient list: Withdrawal Ease Nighttime Formulation:

  • Gaba
  • Melatonin
  • Milk Thistle Ext.
  • Alpha Lipoic Acid
  • Reduced Glutathione
  • Valerian Root Ext. 0.8%
  • Methionine



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