Oxycodone Withdrawal

  • Acute Oxycodone Withdrawal: 3-5 days
  • Post Acute Oxycodone Withdrawal: 1 Week

oxycodone withdrawal duration

What is Oxycodone?

Oxycodone is a semi-synthetic opiate derived from thebaine. It’s prescribed for post-operative, chronic and severe pain. Oxycodone has several variants based on its formulation, coating or other ingredients.

Oxycodone (immediate release)

Oxycodone picture

Oxycodone “Immediate Release”

To my knowledge, “pure” Oxycodone is not prescribed nearly as much as it’s “relatives” Percocet and Oxycontin.

Percocet (Oxycodone + Acetaminophen)


Percocet is available in a variety of strengths

Percocet is one of the most widely prescribed prescription painkillers because it is highly effective for acute pain. It is a schedule 2 drug which means that it is more tightly restricted with respect to triplicate prescription forms and refills.

Oxycontin (extended release)

Oxycontin various strengths

Oxycontin Extended Release Tablets are also available in a variety of strengths

Oxycontin has been very controversial due to high rates of abuse when crushed (to counteract the time release coating) and then either injected or snorted. In 2010, the manufacturer Purdue Pharma took preventative measures to reduce “adulteration”, including applying a new polymer coating to disrupt the release mechanism. But addicts can be very crafty! Many are able to find ways to shoot and snort almost anything. It’s a shame because Oxycontin is a valuable clinical tool if taken as directed.

Withdrawal Symptoms

Like most other opiates, Oxycodone withdrawal symptoms occur when usage is abruptly ended. The acute withdrawal period can result in excruciating discomfort, often making it difficult for those who are physically dependent to stop using Oxycodone. These symptoms fluctuate in intensity and can last days or weeks. Proper medical guidance should be utilized when detoxing from Oxycodone and its other variants. Oxycodone withdrawal is not typically life threatening; however, symptoms can be extraordinarily uncomfortable.

Symptoms may include:

  • Anxiety
  • Diarrhea
  • Nausea
  • Muscle Cramping
  • Restlessness
  • Insomnia
  • Sweating
  • Chills
  • Loss of Appetite

Symptoms Severity Scale Rating

oxycodone withdrawal severity scale

Oxycodone Withdrawal Treatment

  • Non-Medical Treatment: Abrupt cessation of Oxycodone with the assistance of a hospital or rehab center.
  • Medical Treatment: Decrease Oxycodone dose before total elimination of drug intake combined with the administration of methadone or Clonidine.

Oxycodone Facts

  • Oxycodone variants and names: Oxycontin (Controlled Release: 10mg-80mg), Percocet, Roxicodone Percodan
  • Also Called: Hillbilly Heroin, Oxys, Percs, OC’s
  • Administration: Pill form is the most common formulation of Oxycodone but it can be “adulterated” also be administered intra-nasally, rectally, intravenously and intro-muscularly.
  • Half Life of Oxycodone: 3-4.5 hours